Gray whale transcriptome reveals longevity adaptations associated with DNA repair and ubiquitination.

ABSTRACT: One important question in aging research is how differences in genomics and transcriptomics determine the maximum lifespan in various species. Despite recent progress, much is still unclear on the topic, partly due to the lack of samples in nonmodel organisms and due to challenges in direct comparisons of transcriptomes from different species. The novel ranking-based method that we employ here is used to analyze gene expression in the gray whale and compare its de novo assembled transcriptome with that of other long- and short-lived mammals. Gray whales are among the top 1% longest-lived mammals. Despite the extreme environment, or maybe due to a remarkable adaptation to its habitat (intermittent hypoxia, Arctic water, and high pressure), gray whales reach at least the age of 77 years. In

SUBMITTER: Toren D 

PROVIDER: S-EPMC7433004 | biostudies-literature | 2020 Jul

REPOSITORIES: biostudies-literature