Mybl2 rejuvenates heart explant-derived cells from aged donors after myocardial infarction.

ABSTRACT: While cell therapy is emerging as a promising option for patients with ischemic cardiomyopathy (ICM), the influence of advanced donor age and a history of ischemic injury on the reparative performance of these cells are not well defined. As such, intrinsic changes that result from advanced donor age and ischemia are explored in hopes of identifying a molecular candidate capable of restoring the lost reparative potency of heart explant-derived cells (EDCs) used in cell therapy. EDCs were cultured from myocardial biopsies obtained from young or old mice 4 weeks after randomization to experimental myocardial infarction or no intervention. Advanced donor age reduces cell yield while increasing cell senescence and the secretion of senescence-associated cytokines. A history of ischemic injury ma

SUBMITTER: Rafatian G 

PROVIDER: S-EPMC7433005 | biostudies-literature | 2020 Jul

REPOSITORIES: biostudies-literature