The sputum microbiome associated with different sub-types of AECOPD in a Chinese cohort.

ABSTRACT:

Background

Chronic obstructive pulmonary disease (COPD) is one of the most prevalent diseases worldwide. Episodes of acute exacerbations of COPD (AECOPD) are associated with disease severity and progression. Although substantial progress has been made in understanding the dynamics of AECOPD, little is known about the sputum microbiome of AECOPD in the Chinese population.

Methods

In this study, we characterized the sputum microbiomes from sputum specimens collected from healthy controls (n = 10), stable (n = 4), AECOPD (n = 36), and recovery (n = 18) stages by sequencing the V3-V4 region of the 16S rRNA gene with a HiSeq sequencer.

Results

Streptococcus was the most dominant genus among all the different types of sputum. A random forest model was developed to identify

SUBMITTER: Wang J 

PROVIDER: S-EPMC7433052 | biostudies-literature | 2020 Aug

REPOSITORIES: biostudies-literature