Transcriptome analysis of Aedes aegypti Aag2 cells in response to dengue virus-2 infection.

ABSTRACT:

Background

Dengue virus (DENV) is a flavivirus transmitted by mosquitoes that is prevalent in tropical and subtropical countries and has four serotypes (DENV1-4). Aedes aegypti, as the main transmission vector of DENV, exhibits strong infectivity and transmission. With the aim of obtaining a better understanding of the Ae. aegypti-DENV interaction, the transcriptome changes in DENV-2-infected Aag2 cells were studied to describe the immune responses of mosquitoes using the Ae. aegypti Aag2 cell line as a model.

Methods

RNAseq technology was used to sequence the transcripts of the Ae. aegypti Aag2 cell line before and after infection with DENV-2. A bioinformatics analysis was then performed to assess the biological functions of the differentially expressed genes, and the seque

SUBMITTER: Li MJ 

PROVIDER: S-EPMC7433057 | biostudies-literature | 2020 Aug

REPOSITORIES: biostudies-literature