High intensity exercise downregulates FTO mRNA expression during the early stages of recovery in young males and females.

ABSTRACT:

Background

Physical exercise and activity status may modify the effect of the fat mass- and obesity-associated (FTO) genotype on body weight and obesity risk. To understand the interaction between FTO's effect and physical activity, the present study investigated the effects of high and low intensity exercise on FTO mRNA and protein expression, and potential modifiers of exercise-induced changes in FTO in healthy-weighted individuals.

Methods

Twenty-eight untrained males and females (25.4 ± 1.1 years; 73.1 ± 2.0 kg; 178.8 ± 1.4 cm; 39.0 ± 1.2 ml.kg.min^- 1 VO_2peak) were genotyped for the FTO rs9939609 (T > A) polymorphism and performed isocaloric (400 kcal) cycle ergometer exercise on two separate occasions at different intensities: 80% (Hi

SUBMITTER: Danaher J 

PROVIDER: S-EPMC7433063 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature