Efficacy of vitamin D₃ supplementation for the prevention of pulmonary tuberculosis and mortality in HIV: a randomised, double-blind, placebo-controlled trial.

ABSTRACT:

Background

Observational data suggest that low vitamin D status is associated with an increased incidence of pulmonary tuberculosis and mortality among people living with HIV. The primary aims of this study were to assess the effect of vitamin D₃ supplementation on the risk of mortality and incidence of pulmonary tuberculosis among adults initiating antiretroviral therapy (ART).

Methods

This was a randomised, double-blind, placebo-controlled trial of vitamin D₃ supplementation among adults living with HIV who initiated ART and had serum 25-hydroxyvitamin D concentrations of less than 30 ng/mL at four large HIV care and treatment centres in Dar es Salaam, Tanzania. Patients were excluded if they were younger than 18 years, pregnant at the time of randomi

SUBMITTER: Sudfeld CR 

PROVIDER: S-EPMC7433214 | biostudies-literature | 2020 Jul

REPOSITORIES: biostudies-literature