Is the Immunological Response a Bottleneck for Cell Therapy in Neurodegenerative Diseases?

ABSTRACT: Neurodegenerative disorders such as Parkinson's (PD) and Huntington's disease (HD) are characterized by a selective detrimental impact on neurons in a specific brain area. Currently, these diseases have no cures, although some promising trials of therapies that may be able to slow the loss of brain cells are underway. Cell therapy is distinguished by its potential to replace cells to compensate for those lost to the degenerative process and has shown a great potential to replace degenerated neurons in animal models and in clinical trials in PD and HD patients. Fetal-derived neural progenitor cells, embryonic stem cells or induced pluripotent stem cells are the main cell sources that have been tested in cell therapy approaches. Furthermore, new strategies are emerging, such as the use of ad

SUBMITTER: Salado-Manzano C 

PROVIDER: S-EPMC7433375 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature