Associations of mammographic breast density with breast stem cell marker-defined breast cancer subtypes.

ABSTRACT:

Purpose

High mammographic breast density is a strong, well-established breast cancer risk factor. Whether stem cells may explain high breast cancer risk in dense breasts is unknown. We investigated the association between breast density and breast cancer risk by the status of stem cell markers CD44, CD24, and ALDH1A1 in the tumor.

Methods

We included 223 women with primary invasive or in situ breast cancer and 399 age-matched controls from Mayo Clinic Mammography Study. Percent breast density (PD), absolute dense area (DA), and non-dense area (NDA) were assessed using computer-assisted thresholding technique. Immunohistochemical analysis of the markers was performed on tumor tissue microarrays according to a standard protocol. We used polytomous logistic regression to quanti

SUBMITTER: Yaghjyan L 

PROVIDER: S-EPMC7433400 | biostudies-literature | 2019 Oct

REPOSITORIES: biostudies-literature