An acute seizure prior to memory reactivation transiently impairs associative memory performance in C57BL/6J mice.

ABSTRACT: Memory deficits significantly decrease an individual's quality of life and are a pervasive comorbidity of epilepsy. Despite the various distinct processes of memory, the majority of epilepsy research has focused on seizures during the encoding phase of memory, therefore the effects of a seizure on other memory processes is relatively unknown. In the present study, we investigated how a single seizure affects memory reactivation in C57BL/6J adult mice using an associative conditioning paradigm. Initially, mice were trained to associate a tone (conditioned stimulus), with the presence of a shock (unconditioned stimulus). Flurothyl was then administered 1 h before, 1 h after, or 6 h before a memory reactivation trial. The learned association was then assessed by presenting a conditioned stimu

SUBMITTER: Binder MS 

PROVIDER: S-EPMC7433655 | biostudies-literature | 2020 Sep

REPOSITORIES: biostudies-literature