Performance of the MasSpec Pen for Rapid Diagnosis of Ovarian Cancer.

ABSTRACT:

Background

Accurate tissue diagnosis during ovarian cancer surgery is critical to maximize cancer excision and define treatment options. Yet, current methods for intraoperative tissue evaluation can be time intensive and subjective. We have developed a handheld and biocompatible device coupled to a mass spectrometer, the MasSpec Pen, which uses a discrete water droplet for molecular extraction and rapid tissue diagnosis. Here we evaluated the performance of this technology for ovarian cancer diagnosis across different sample sets, tissue types, and mass spectrometry systems.

Methods

MasSpec Pen analyses were performed on 192 ovarian, fallopian tube, and peritoneum tissue samples. Samples were evaluated by expert pathologists to confirm diagnosis. Performance using an Orbitra

SUBMITTER: Sans M 

PROVIDER: S-EPMC7433751 | biostudies-literature | 2019 May

REPOSITORIES: biostudies-literature