Blood product transfusion and mortality in neonatal extracorporeal membrane oxygenation.

ABSTRACT:

Background

Neonates receiving extracorporeal membrane oxygenation (ECMO) support are transfused large volumes of red blood cells (RBCs) and platelets (PLTs). Transfusions are often administered in response to specific, but largely unstudied thresholds. The aim of this study is to examine the relationship between RBC and PLT transfusion rates and mortality in neonates receiving ECMO support.

Study design and methods

We retrospectively examined outcomes of neonates receiving ECMO support in the neonatal intensive care unit (NICU) for respiratory failure between 2010 and 2016 at a single quaternary-referral NICU. We examined the association between RBC and PLT transfusion rate (mL per kg per day) and in-hospital mortality, adjusting for confounding by using a validated composit

SUBMITTER: Keene SD 

PROVIDER: S-EPMC7433883 | biostudies-literature | 2020 Feb

REPOSITORIES: biostudies-literature