Ontology highlight
ABSTRACT:
SUBMITTER: Jones JM
PROVIDER: S-EPMC7434442 | biostudies-literature | 2020 Aug
REPOSITORIES: biostudies-literature
Jones Jessica M JM Foster William W Twomey Colin R CR Burdge Justin J Ahmed Osama M OM Pereira Talmo D TD Wojick Jessica A JA Corder Gregory G Plotkin Joshua B JB Abdus-Saboor Ishmail I
eLife 20200806
Objective and automatic measurement of pain in mice remains a barrier for discovery in neuroscience. Here, we capture paw kinematics during pain behavior in mice with high-speed videography and automated paw tracking with machine and deep learning approaches. Our statistical software platform, PAWS (Pain Assessment at Withdrawal Speeds), uses a univariate projection of paw position over time to automatically quantify seven behavioral features that are combined into a single, univariate pain scor ...[more]