Ontology highlight
ABSTRACT:
SUBMITTER: Fulcher JA
PROVIDER: S-EPMC7434464 | biostudies-literature | 2019 Aug
REPOSITORIES: biostudies-literature
Fulcher Jennifer A JA Tamshen Kyle K Wollenberg Alexander L AL Kickhoefer Valerie A VA Mrazek Jan J Elliott Julie J Ibarrondo F Javier FJ Anton Peter A PA Rome Leonard H LH Maynard Heather D HD Deming Timothy T Yang Otto O OO
Bioconjugate chemistry 20190716 8
"Vaults" are ubiquitously expressed endogenous ribonucleoprotein nanoparticles with potential utility for targeted drug delivery. Here, we show that recombinant human vault nanoparticles are readily engulfed by certain key human peripheral blood mononuclear cells (PBMC), predominately dendritic cells, monocytes/macrophages, and activated T cells. As these cell types are the primary targets for human immunodeficiency virus type 1 (HIV-1) infection, we examined the utility of recombinant human vau ...[more]