To what extent should the intestinal be resected proximally after radiotherapy: hint from a pathological view.

ABSTRACT:

Background

Neoadjuvant chemoradiotherapy (nCRT) is associated with post-operative anastomotic complications in rectal-cancer patients. Anastomosis involving at least one non-irradiated margin reportedly significantly reduces the risk of post-operative anastomotic complications in radiation enteritis. However, the exact scope of radiotherapy on the remaining sigmoid colon remains unknown.

Methods

We evaluated the radiation damage of proximally resected colorectal segments in 44 patients with rectal cancer, who received nCRT followed by conventional resection (nCRT-C, n = 21) or proximally extended resection (nCRT-E, n = 23). The segments from another 13 patients undergoing neoadjuvant chemotherapy (nCT) were used as control. We dissected these samples at a dista

SUBMITTER: Wu PH 

PROVIDER: S-EPMC7434582 | biostudies-literature | 2020 Aug

REPOSITORIES: biostudies-literature