Clinical and genetic analysis of lipoprotein glomerulopathy patients caused by APOE mutations.

ABSTRACT:

Background

Lipoprotein glomerulopathy (LPG) is a rare kidney disease caused by APOE mutations. The aim of this study was to correlate the genetic and clinical features of LPG.

Methods

Totally eight LPG patients were recruited in this study and Sanger sequencing of APOE was performed for all available family members. Clinical and histological features were analyzed. A literature review of LPG was also conducted.

Results

Genetic analysis revealed five patients with APOE-Kyoto, two with APOE-Osaka/Kurashiki, and one with APOE-Chicago mutations. LPG patients with urine protein reduced more than 50% had a slower decrease in renal function than those with less urine protein reduction (estimated glomerular filtration rate reduction rate -5.0 ± 0.8 vs. 1.5 ± 0.7 ml/min per 1.

SUBMITTER: Yang M 

PROVIDER: S-EPMC7434605 | biostudies-literature | 2020 Aug

REPOSITORIES: biostudies-literature