Metabolomics Profiles of Smokers from Two Ethnic Groups with Differing Lung Cancer Risk.

ABSTRACT: African American (AA) smokers are at a higher risk of developing lung cancer compared to whites. The variations in the metabolism of nicotine and tobacco-derived carcinogens in these groups were reported previously with the levels of nicotine metabolites and carcinogen-derived metabolites measured using targeted approaches. While useful, these targeted strategies are not able to detect global metabolic changes for use in predicting the detrimental effects of tobacco use and ultimately lung cancer susceptibility among smokers. To address this limitation, we have performed global untargeted metabolomics profiling in urine of AA and white smokers to characterize the pattern of metabolites, identify differentially regulated pathways, and correlate these profiles with the observed variations in

SUBMITTER: Dator R 

PROVIDER: S-EPMC7434657 | biostudies-literature | 2020 Aug

REPOSITORIES: biostudies-literature