Precision mapping of the epileptogenic network with low- and high-frequency stimulation of anterior nucleus of thalamus.

ABSTRACT:

Objective

The goal of thalamic deep brain stimulation in epilepsy is to engage and modulate the epileptogenic network. We demonstrate how the anterior nucleus of thalamus (ANT) stimulation engages the epileptogenic network using electrophysiological measures (gamma response and post-stimulation excitability).

Methods

Five patients with suspected temporal lobe epilepsy syndrome, undergoing stereo-electroencephalography (SEEG), were enrolled in the IRB approved study to undergo recording and stimulation of the ANT. We analyzed the extent of gamma-band response (activation or suppression) and post-stimulation change in excitability in various cortical regions during low (10 Hz) and high (50 Hz) frequency stimulations.

Results

10 Hz stimulation increased cortical gamma, w

SUBMITTER: Chaitanya G 

PROVIDER: S-EPMC7434689 | biostudies-literature | 2020 Sep

REPOSITORIES: biostudies-literature