Corneal Epithelial Thickness Measured Using Anterior Segment Optical Coherence Tomography as a Diagnostic Parameter for Limbal Stem Cell Deficiency.

ABSTRACT:

Objective

Using anterior segment optical coherence tomography (AS-OCT), we investigated the epithelial thickness (ET) of the central cornea and limbal regions in patients with limbal stem cell deficiency (LSCD) as a diagnostic and staging parameter.

Design

Prospective, cross-sectional study.

Methods

The central corneal epithelium thickness (CET) and maximum limbal epithelium thickness (mLET) were measured in the superior, inferior, nasal, and temporal limbus on AS-OCT images of the normal and eyes with LSCD. CET was obtained by 1-point (OCT-CET1) and 3-point measurement (OCT-CET3). The values of OCT-CET1 and OCT-CET3 were compared to the CET obtained with in vivo confocal microscopy (IVCM-CET).

Results

Sixty-eight eyes of 50 patients with LSCD and 52 eyes of 34

SUBMITTER: Liang Q 

PROVIDER: S-EPMC7434708 | biostudies-literature | 2020 Aug

REPOSITORIES: biostudies-literature