LXA₄-FPR2 signaling regulates radiation-induced pulmonary fibrosis via crosstalk with TGF-β/Smad signaling.

ABSTRACT: Radiation therapy is an important modality in the treatment of lung cancer, but it can lead to radiation pneumonitis, and eventually radiation fibrosis. To date, only few available drugs can effectively manage radiation-induced pulmonary fibrosis. Lipoxins are endogenous molecules exhibit anti-inflammatory and pro-resolving effects. These molecules play a vital role in reducing excessive tissue injury and chronic inflammation; however, their effects on radiation-induced lung injury (RILI) are unknown. In this study, we investigated the effects of lipoxin A₄ (LXA₄) on RILI using our specialized small-animal model of RILI following focal-ablative lung irradiation (IR). LXA₄ significantly inhibited immune-cell recruitment and reduced IR-induced expression of p

SUBMITTER: Kim H 

PROVIDER: S-EPMC7434774 | biostudies-literature | 2020 Aug

REPOSITORIES: biostudies-literature