Development of a Novel Positron Emission Tomography (PET) Radiotracer Targeting Bromodomain and Extra-Terminal Domain (BET) Family Proteins.

ABSTRACT: Bromodomain and extra-terminal domain (BET) family proteins have become a hot research area because of their close relationship with a variety of human diseases. The non-invasive imaging technique, such as positron emission tomography (PET), provides a powerful tool to visualize and quantify the BET family proteins that accelerating the investigation of this domain. Herein, we describe the development of a promising PET probe, [ ¹¹ C]1, specifically targeting BET family proteins based on the potent BET inhibitor CF53. [ ¹¹ C]1 was successfully radio-synthesized with good yield and high purity after the optimization of radiolabeling conditions. The in vivo bio-activities evaluation of [ ¹¹ C]1 was performed us

SUBMITTER: Bai P 

PROVIDER: S-EPMC7434981 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature