The role of sex in the innate and adaptive immune environment of metastatic colorectal cancer.

ABSTRACT:

Background

Women with colorectal cancer (CRC) have a significant survival advantage over men. Sex influences on the tumour microenvironment (TME) are not well characterised, despite the importance of immune response in CRC. We hypothesised that sex-divergent immune responses could contribute to survival.

Methods

Using a murine model of metastatic CRC, we examined T cells, macrophages, and cytokines locally and systemically. TME and serum cytokines were measured by multiplex bead-based arrays, while FCA was used to identify cells and phenotypes. IHC provided spatial confirmation of T cell infiltration.

Results

Females had increased survival and T cell infiltration. CD8, CD4 and Th2 populations correlated with longer survival. Males had increased serum levels of chemoki

SUBMITTER: Ray AL 

PROVIDER: S-EPMC7435180 | biostudies-literature | 2020 Aug

REPOSITORIES: biostudies-literature