Targeting cPLA₂ derived lipid hydroperoxides as a potential intervention for sarcopenia.

ABSTRACT: Defects in neuromuscular innervation contribute significantly to the age-related decline in muscle mass and function (sarcopenia). Our previous studies demonstrated that denervation induces muscle mitochondrial hydroperoxide production (H₂O₂ and lipid hydroperoxides (LOOHs)). Here we define the relative contribution of mitochondrial electron transport chain (ETC) derived H₂O₂ versus cytosolic phospholipase A₂ (cPLA₂) derived LOOHs in neurogenic muscle atrophy. We show that denervation increases muscle cPLA₂ protein content, activity, and metabolites downstream of cPLA₂ including LOOHs. Increased scavenging of mitochondrial H₂O₂ does not protect against denervation atrophy, suggesti

SUBMITTER: Pharaoh G 

PROVIDER: S-EPMC7435184 | biostudies-literature | 2020 Aug

REPOSITORIES: biostudies-literature