High-Yield Production of Biohybrid Microalgae for On-Demand Cargo Delivery.

ABSTRACT: Biohybrid microswimmers exploit the swimming and navigation of a motile microorganism to target and deliver cargo molecules in a wide range of biomedical applications. Medical biohybrid microswimmers suffer from low manufacturing yields, which would significantly limit their potential applications. In the present study, a biohybrid design strategy is reported, where a thin and soft uniform coating layer is noncovalently assembled around a motile microorganism. Chlamydomonas reinhardtii (a single-cell green alga) is used in the design as a biological model microorganism along with polymer-nanoparticle matrix as the synthetic component, reaching a manufacturing efficiency of ≈90%. Natural biopolymer chitosan is used as a binder to efficiently coat the cell wall of the microalgae with

SUBMITTER: Akolpoglu MB 

PROVIDER: S-EPMC7435244 | biostudies-literature | 2020 Aug

REPOSITORIES: biostudies-literature