Caveolin1 and YAP drive mechanically induced mesothelial to mesenchymal transition and fibrosis.

ABSTRACT: Despite their emerging relevance to fully understand disease pathogenesis, we have as yet a poor understanding as to how biomechanical signals are integrated with specific biochemical pathways to determine cell behaviour. Mesothelial-to-mesenchymal transition (MMT) markers colocalized with TGF-β1-dependent signaling and yes-associated protein (YAP) activation across biopsies from different pathologies exhibiting peritoneal fibrosis, supporting mechanotransduction as a central driving component of these class of fibrotic lesions and its crosstalk with specific signaling pathways. Transcriptome and proteome profiling of the response of mesothelial cells (MCs) to linear cyclic stretch revealed molecular changes compatible with bona fide MMT, which (i) overlapped with established YAP target ge

SUBMITTER: Strippoli R 

PROVIDER: S-EPMC7435273 | biostudies-literature | 2020 Aug

REPOSITORIES: biostudies-literature