Hyperpolarization of Nitrile Compounds Using Signal Amplification by Reversible Exchange.

ABSTRACT: Signal Amplification by Reversible Exchange (SABRE), a hyperpolarization technique, has been harnessed as a powerful tool to achieve useful hyperpolarized materials by polarization transfer from parahydrogen. In this study, we systemically applied SABRE to a series of nitrile compounds, which have been rarely investigated. By performing SABRE in various magnetic fields and concentrations on nitrile compounds, we unveiled its hyperpolarization properties to maximize the spin polarization and its transfer to the next spins. Through this sequential study, we obtained a ~130-fold enhancement for several nitrile compounds, which is the highest number ever reported for the nitrile compounds. Our study revealed that the spin polarization on hydrogens decreases with longer distances from the nitri

SUBMITTER: Kim S 

PROVIDER: S-EPMC7435364 | biostudies-literature | 2020 Jul

REPOSITORIES: biostudies-literature