Crosslinking of Chitosan with Dialdehyde Chitosan as a New Approach for Biomedical Applications.

ABSTRACT: Materials based on natural high molecular compounds are particularly interesting for biomedical applications. It is known that the cross-linking agent used for preparation of biomacromolecule-based materials is as important as used biopolymer. Therefore, natural cross-linkers containing reactive carbonyl groups are of great interest especially for modifying properties of natural polysaccharides. One of the most popular cross-linking agents is glutaraldehyde. Nevertheless, the unreacted particles can be released from the cross-linked material and cause cytotoxic effects. This can be eliminated when using a cross-linker based e.g., on polysaccharides. This article describes quick and efficient synthesis of dialdehyde chitosan (DACS) and its application for the preparation of chitosan films.

SUBMITTER: Wegrzynowska-Drzymalska K 

PROVIDER: S-EPMC7435867 | biostudies-literature | 2020 Aug

REPOSITORIES: biostudies-literature