Decorin Protects Cardiac Myocytes against Simulated Ischemia/Reperfusion Injury.

ABSTRACT: Search for new cardioprotective therapies is of great importance since no cardioprotective drugs are available on the market. In line with this need, several natural biomolecules have been extensively tested for their potential cardioprotective effects. Previously, we have shown that biglycan, a member of a diverse group of small leucine-rich proteoglycans, enhanced the expression of cardioprotective genes and decreased ischemia/reperfusion-induced cardiomyocyte death via a TLR-4 dependent mechanism. Therefore, in the present study we aimed to test whether decorin, a small leucine-rich proteoglycan closely related to biglycan, could exert cardiocytoprotection and to reveal possible downstream signaling pathways. Methods: Primary cardiomyocytes isolated from neonatal and adult rat hearts we

SUBMITTER: Gaspar R 

PROVIDER: S-EPMC7436189 | biostudies-literature | 2020 Jul

REPOSITORIES: biostudies-literature