Fatty Acid Allosteric Regulation of C-H Activation in Plant and Animal Lipoxygenases.
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ABSTRACT:
SUBMITTER: Offenbacher AR
PROVIDER: S-EPMC7436259 | biostudies-literature | 2020 Jul
REPOSITORIES: biostudies-literature
Publications
Fatty Acid Allosteric Regulation of C-H Activation in Plant and Animal Lipoxygenases.
Offenbacher Adam R AR Holman Theodore R TR
Molecules (Basel, Switzerland) 20200724 15
Lipoxygenases (LOXs) catalyze the (per) oxidation of fatty acids that serve as important mediators for cell signaling and inflammation. These reactions are initiated by a C-H activation step that is allosterically regulated in plant and animal enzymes. LOXs from higher eukaryotes are equipped with an N-terminal PLAT (Polycystin-1, Lipoxygenase, Alpha-Toxin) domain that has been implicated to bind to small molecule allosteric effectors, which in turn modulate substrate specificity and the rate-li ...[more]
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