Period Family of Clock Genes as Novel Predictors of Survival in Human Cancer: A Systematic Review and Meta-Analysis.

ABSTRACT:

Background

Period genes are important core clock genes, including PER1, PER2, and PER3. A number of studies have demonstrated that the abnormal expression of the PER gene family of clock genes is associated with the survival and prognosis of patients with cancer; however, the sample sizes included in the majority of these studies were small, and the reported results were inconsistent. This study was the first to collect the relevant publications to systematically evaluate the value of the expression of the PER gene family in the prediction of survival and prognosis of human tumors.

Methods

The PubMed, Cochrane Library, Embase, and Web of Science databases were searched systematically, and a meta-analysis was performed.

Results

A tota

SUBMITTER: Deng F 

PROVIDER: S-EPMC7436287 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature