Extended Polysaccharide Analysis within the Liposomal Encapsulation of Polysaccharides System.

ABSTRACT: The Liposomal Encapsulation of Polysaccharides (LEPS) dual antigen vaccine carrier system was assessed across two distinct polysaccharides for encapsulation efficiency, subsequent liposomal surface adornment with protein, adjuvant addition, and size and charge metrics. The polysaccharides derive from two different serotypes of Streptococcus pneumoniae and have traditionally served as the active ingredients of vaccines against pneumococcal disease. The LEPS system was designed to mimic glycoconjugate vaccines that covalently couple polysaccharides to protein carriers; however, the LEPS system uses a noncovalent co-localization mechanism through protein liposomal surface attachment. In an effort to more thoroughly characterize the LEPS system across individual vaccine components and thus sup

SUBMITTER: Nayerhoda R 

PROVIDER: S-EPMC7436327 | biostudies-literature | 2020 Jul

REPOSITORIES: biostudies-literature