Preterm delivery and long term mortality in women: national cohort and co-sibling study.

ABSTRACT:

Objectives

To examine the long term mortality associated with preterm delivery in a large population based cohort of women, and to assess for potential confounding by shared familial factors.

Design

National cohort study.

Setting

Sweden.

Participants

All 2 189 477 women with a singleton delivery in 1973-2015.

Main outcome measures

All cause and cause specific mortality up to 2016, identified from nationwide death records. Cox regression was used to calculate hazard ratios while adjusting for confounders, and co-sibling analyses assessed the potential influence of unmeasured shared familial (genetic and environmental) factors.

Results

In 50.7 million person years of follow-up, 76 535 (3.5%) women died (median age at death was 57.6). In the 10 years

SUBMITTER: Crump C 

PROVIDER: S-EPMC7436341 | biostudies-literature | 2020 Aug

REPOSITORIES: biostudies-literature