Identification of Viruses in Patients With Postviral Olfactory Dysfunction by Multiplex Reverse-Transcription Polymerase Chain Reaction.

ABSTRACT:

Objectives/hypothesis

To investigate causative viruses in patients with postviral olfactory disorders (PVOD).

Study design

Case-control study.

Methods

One hundred fifty-one consecutive patients diagnosed with PVOD were enrolled, and samples from 38 patients who visited the doctor within 3 months of symptom onset were collected and analyzed. Thirty-two individuals who underwent surgery for nasal septal deviation during the same time period were collected as the control group. The Sniffin' Sticks psychophysical olfactory test was used to evaluate olfactory function. Olfactory cleft specimens were collected using nasopharyngeal flocked swabs (COPAN FLOQSwabs). Eighteen viruses were tested for with the Luminex xTAG RVP FAST v2 Assay Kit.

Results

Out of the 38 patie

SUBMITTER: Tian J 

PROVIDER: S-EPMC7436707 | biostudies-literature | 2021 Jan

REPOSITORIES: biostudies-literature