Lung ultrasound predicts histological lung injury in a neonatal model of acute respiratory distress syndrome.

ABSTRACT:

Rationale

Point-of-care ultrasound (POCUS) is used to evaluate pulmonary edema in adults with acute respiratory distress syndrome (ARDS). Its use has not been validated in neonatal models.

Objectives

We compared an in vivo lung ultrasound score against clinical and histological markers of acute lung injury, in a neonatal animal model, hypothesizing that POCUS would sensitively diagnose early acute lung injury in neonates and discern its severity.

Methods

Fifteen anesthetized, ventilated 3-day-old neonatal piglets were divided into controls, moderate lung injury, or severe lung injury by graded treatment with oleic acid. Degree of lung injury was quantified at baseline, immediately after oleic acid administration, and 1 hour after the evolution of acute lung injury, by

SUBMITTER: Elsayed YN 

PROVIDER: S-EPMC7436735 | biostudies-literature | 2020 Nov

REPOSITORIES: biostudies-literature