Evaluation of medicinal herbs as a potential therapeutic option against SARS-CoV-2 targeting its main protease.

ABSTRACT: The COVID-19 disease caused by the SARS-CoV-2 has emerged as a worldwide pandemic and caused huge damage to the lives and economy of more than hundred countries. As on May 10, 2020, more than 4,153,300 people stand infected from the virus due to an unprecedented rate of transmission and 282,700 have lost their lives because of the disease. In this context, medicinal plants may provide a way to treat the disease by targeting specific essential proteins of the virus. We screened about 51 medicinal plants and found that Tea (Camellia sinensis) and Haritaki (Terminalia chebula) has potential against SARS-COV-2 3CL^pro , with an IC₅₀ for Green Tea as 8.9 ± 0.5 μg/ml and Haritaki 8.8 ± 0.5 μg/ml. The in-silico studies suggested that Tea component Thearubigins binds to the cy

SUBMITTER: Upadhyay S 

PROVIDER: S-EPMC7436756 | biostudies-literature | 2020 Dec

REPOSITORIES: biostudies-literature