Triclosan induces ROS-dependent cell death and autophagy in A375 melanoma cells.

ABSTRACT: Melanoma is a common type of cutaneous tumor, but current drug treatments do not satisfy clinical practice requirements. At present, mitochondrial uncoupling is an effective antitumor treatment. Triclosan, a common antimicrobial, also acts as a mitochondrial uncoupler. The aims of the present study were to investigate the effects of triclosan on melanoma cells and the underlying mechanisms. Mitochondrial membrane potential (MMP), mitochondrial morphology, mitochondrial reactive oxygen species (mito-ROS), intracellular superoxide anion and [Ca²⁺]_i were measured using confocal microscopy. It was found that triclosan application was associated with decreased A375 cell viability in a dose- and time-dependent manner and these effects may have cell specificity. Furthermore,

SUBMITTER: Jin J 

PROVIDER: S-EPMC7436935 | biostudies-literature | 2020 Oct

REPOSITORIES: biostudies-literature