Clinical implications of prospective genomic profiling of metastatic breast cancer patients.

ABSTRACT:

Background

Metastatic breast cancer remains incurable. Next-generation sequencing (NGS) offers the ability to identify actionable genomic alterations in tumours which may then be matched with targeted therapies, but the implementation and utility of this approach is not well defined for patients with metastatic breast cancer.

Methods

We recruited patients with advanced breast cancer of any subtype for prospective targeted NGS of their most recent tumour samples, using a panel of 108 breast cancer-specific genes. Genes were classified as actionable or non-actionable using the European Society of Medical Oncology Scale for Clinical Actionability of Molecular Targets (ESCAT) guidelines.

Results

Between February 2014 and May 2019, 322 patients were enrolled onto the study

SUBMITTER: van Geelen CT 

PROVIDER: S-EPMC7436992 | biostudies-literature | 2020 Aug

REPOSITORIES: biostudies-literature