Large-scale discovery of male reproductive tract-specific genes through analysis of RNA-seq datasets.

ABSTRACT:

Background

The development of a safe, effective, reversible, non-hormonal contraceptive method for men has been an ongoing effort for the past few decades. However, despite significant progress on elucidating the function of key proteins involved in reproduction, understanding male reproductive physiology is limited by incomplete information on the genes expressed in reproductive tissues, and no contraceptive targets have so far reached clinical trials. To advance product development, further identification of novel reproductive tract-specific genes leading to potentially druggable protein targets is imperative.

Results

In this study, we expand on previous single tissue, single species studies by integrating analysis of publicly available human and mouse RNA-seq datasets who

SUBMITTER: Robertson MJ 

PROVIDER: S-EPMC7436996 | biostudies-literature | 2020 Aug

REPOSITORIES: biostudies-literature