In utero and childhood exposure to tobacco smoke and multi-layer molecular signatures in children.

ABSTRACT:

Background

The adverse health effects of early life exposure to tobacco smoking have been widely reported. In spite of this, the underlying molecular mechanisms of in utero and postnatal exposure to tobacco smoke are only partially understood. Here, we aimed to identify multi-layer molecular signatures associated with exposure to tobacco smoke in these two exposure windows.

Methods

We investigated the associations of maternal smoking during pregnancy and childhood secondhand smoke (SHS) exposure with molecular features measured in 1203 European children (mean age 8.1 years) from the Human Early Life Exposome (HELIX) project. Molecular features, covering 4 layers, included blood DNA methylation and gene and miRNA transcription, plasma proteins, and sera and urinary metabolite

SUBMITTER: Vives-Usano M 

PROVIDER: S-EPMC7437049 | biostudies-literature | 2020 Aug

REPOSITORIES: biostudies-literature