Association of Bacteroides acidifaciens relative abundance with high-fibre diet-associated radiosensitisation.

ABSTRACT:

Background

Patients with pelvic malignancies often receive radiosensitising chemotherapy with radiotherapy to improve survival; however, this is at the expense of increased normal tissue toxicity, particularly in elderly patients. Here, we explore if an alternative, low-cost, and non-toxic approach can achieve radiosensitisation in mice transplanted with human bladder cancer cells. Other investigators have shown slower growth of transplanted tumours in mice fed high-fibre diets. We hypothesised that mice fed a high-fibre diet would have improved tumour control following ionising radiation (IR) and that this would be mediated through the gut microbiota.

Results

We investigated the effects of four different diets (low-fibre, soluble high-fibre, insoluble high-fibre, and mixed

SUBMITTER: Then CK 

PROVIDER: S-EPMC7437060 | biostudies-literature | 2020 Aug

REPOSITORIES: biostudies-literature