Considerations for target oxygen saturation in COVID-19 patients: are we under-shooting?

ABSTRACT:

Background

The current target oxygen saturation range for patients with COVID-19 recommended by the National Institutes of Health is 92-96%.

Main body

This article critically examines the evidence guiding current target oxygen saturation recommendation for COVID-19 patients, and raises important concerns in the extrapolation of data from the two studies stated to be guiding the recommendation. Next, it examines the influence of hypoxia on upregulation of ACE2 (target receptor for SARS-CoV-2 entry) expression, with supporting transcriptomic analysis of a publicly available gene expression profile dataset of human renal proximal tubular epithelial cells cultured in normoxic or hypoxic conditions. Finally, it discusses potential implications of specific clinical observations an

SUBMITTER: Shenoy N 

PROVIDER: S-EPMC7437106 | biostudies-literature | 2020 Aug

REPOSITORIES: biostudies-literature