Epstein-Barr virus infection and genome polymorphisms on gastric remnant carcinoma: a meta-analysis.

ABSTRACT:

Background

Previous studies reported that Epstein-Barr virus (EBV) may play a causal role in the pathogenesis of gastric remnant carcinoma (GRC). However, there was still some controversy.

Methods

Articles published until July 15, 2020, in PubMed, MEDLINE, Embase and CNKI databases were selected. According to the inclusion criteria, corresponding data of included articles were abstracted and used for statistical analysis.

Results

Thirteen papers were finally enrolled, nine of which showed the result that the risk of EBV infection rate in the GRC was higher than conventional gastric carcinoma (OR = 5.22, 95% CI 3.89-7.00). In addition, we found that EBV associated GRC (EBVaGRC) had higher rate of Billroth-II (OR = 3.80, 95% CI 1.90-7.57), carcinoma in anastomotic site

SUBMITTER: Lu C 

PROVIDER: S-EPMC7437139 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature