Immune parameters associated with survival in metaplastic breast cancer.

ABSTRACT:

Background

Metaplastic breast carcinoma (MBC) is a rare histological type of breast cancer, which commonly shows resistance to standard therapies and is associated with poor prognosis. The immune microenvironment in MBC and its significance has not been well established due to its low incurrence rate and complex components. We aimed to investigate the diversity of immune parameters including subsets of TILs and PDL1/PD1 expression in MBC, as well as its correlation with prognosis.

Methods

A total of 60 patients diagnosed with MBC from January 2006 to December 2017 were included in our study. The percentage (%) and quantification (per mm²) of TILs and presence of tertiary lymphoid structures (TLS) were evaluated by hematoxylin and eosin staining (HE). The quantific

SUBMITTER: Chao X 

PROVIDER: S-EPMC7437173 | biostudies-literature | 2020 Aug

REPOSITORIES: biostudies-literature