Moesin, an Ezrin/Radixin/Moesin Family Member, Regulates Hepatic Fibrosis.

ABSTRACT:

Background and aims

Moesin, an ezrin/radixin/moesin family member, is involved in the regulation of cell adhesion, polarity, and migration by cross-linking between the actin cytoskeleton and plasma membrane. The primary effector cell in hepatic fibrosis is the hepatic stellate cell (HSC), which undergoes activation during liver injury leading to increased extracellular matrix production.

Approach and results

Here, we have hypothesized that moesin plays a critical role in linking the HSC cytoskeleton to the fibrogenic cascade during HSC activation. Moesin phosphorylation was up-regulated during HSC activation and fibrogenesis. Using moesin wild-type (WT) and mutant constructs (phosphomimicking T558D and nonphosphorylatable T558A), we found that cellular motility and contracti

SUBMITTER: Karvar S 

PROVIDER: S-EPMC7437180 | biostudies-literature | 2020 Sep

REPOSITORIES: biostudies-literature