Arg399Gln XRCC1 Polymorphism and Risk of Squamous Cell Carcinoma of the Head and Neck in Jordanian Patients.

ABSTRACT:

Background and objective

X-ray repair cross-complementing group1 (XRCC1) is a key protein in base excision repair and closely associated with the coordination of the base excision repair pathway. Many studies have focused on XRCC1 SNPs and have shown an associated between these SNPs and the risk of several types of cancers, including head and neck cancer. There are many single nucleotide polymorphisms XRCC1 gene (SNPs) and the most common SNP that result in amino acid substitutions is exon 10 (Arg399Gln). This study aimed to investigate the association between Arg399Gln SNP and the risk of squamous cell carcinoma of the head and neck.

Material and method

Ninety nine patients with squamous cell carcinomas of the head and neck and 89 healthy adult controls were enrolled in thi

SUBMITTER: Sobiahe A 

PROVIDER: S-EPMC7437344 | biostudies-literature | 2020 Mar

REPOSITORIES: biostudies-literature