A novel method for calculating beta band burst durations in Parkinson's disease using a physiological baseline.

ABSTRACT:

Background

Pathologically prolonged bursts of neural activity in the 8-30 Hz frequency range in Parkinson's disease have been measured using high power event detector thresholds.

New method

This study introduces a novel method for determining beta bursts using a power baseline based on spectral activity that overlapped a simulated 1/f spectrum. We used resting state local field potentials from people with Parkinson's disease and a simulated 1/f signal to measure beta burst durations, to demonstrate how tuning parameters (i.e., bandwidth and center frequency) affect burst durations, to compare burst duration distributions with high power threshold methods, and to study the effect of increasing neurostimulation intensities on burst duration.

Results

The baseline method

SUBMITTER: Anderson RW 

PROVIDER: S-EPMC7437353 | biostudies-literature | 2020 Sep

REPOSITORIES: biostudies-literature