Effects of aquaporin-lipid molar ratio on the permeability of an aquaporin Z-phospholipid membrane system.

ABSTRACT: Aquaporins are water-permeable membrane-channel proteins found in biological cell membranes that selectively exclude ions and large molecules and have high water permeability, which makes them promising candidates for water desalination systems. To effectively apply the properties of aquaporins in the desalination process, many studies have been conducted on aquaporin-lipid membrane systems using phospholipids, which are the main component of cell membranes. Many parametric studies have evaluated the permeability of such systems with various aquaporin types and lipid compositions. In this study, we performed molecular dynamics simulations for four cases with different protein-lipid molar ratios (1:50, 1:75, 1:100, and 1:150) between aquaporin Z and the phospholipids, and we propose a possi

SUBMITTER: Kim H 

PROVIDER: S-EPMC7437467 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature