Fasciola hepatica serine protease inhibitor family (serpins): Purposely crafted for regulating host proteases.

ABSTRACT: Serine protease inhibitors (serpins) regulate proteolytic events within diverse biological processes, including digestion, coagulation, inflammation and immune responses. The presence of serpins in Fasciola hepatica excretory-secretory products indicates that the parasite exploits these to regulate proteases encountered during its development within vertebrate hosts. Interrogation of the F. hepatica genome identified a multi-gene serpin family of seven members that has expanded by gene duplication and divergence to create an array of inhibitors with distinct specificities. We investigated the molecular properties and functions of two representatives, FhSrp1 and FhSrp2, highly expressed in the invasive newly excysted juvenile (NEJ). Consistent with marked differences in the reactive centre

SUBMITTER: De Marco Verissimo C 

PROVIDER: S-EPMC7437470 | biostudies-literature | 2020 Aug

REPOSITORIES: biostudies-literature