Decoding epigenetic codes: new frontiers in exploring recovery from spinal cord injury.

ABSTRACT: Spinal cord injury that results in severe neurological disability is often incurable. The poor clinical outcome of spinal cord injury is mainly caused by the failure to reconstruct the injured neural circuits. Several intrinsic and extrinsic determinants contribute to this inability to reconnect. Epigenetic regulation acts as the driving force for multiple pathological and physiological processes in the central nervous system by modulating the expression of certain critical genes. Recent studies have demonstrated that post-SCI alteration of epigenetic landmarks is strongly associated with axon regeneration, glial activation and neurogenesis. These findings not only establish a theoretical foundation for further exploration of spinal cord injury, but also provide new avenues for the clinica

SUBMITTER: Zhang BY 

PROVIDER: S-EPMC7437595 | biostudies-literature | 2020 Sep

REPOSITORIES: biostudies-literature