Identification and characterization of cellular heterogeneity within the developing renal interstitium.

ABSTRACT: Kidney formation requires the coordinated growth of multiple cell types including the collecting ducts, nephrons, vasculature and interstitium. There is a long-held belief that interactions between progenitors of the collecting ducts and nephrons are primarily responsible for kidney development. However, over the last several years, it has become increasingly clear that multiple aspects of kidney development require signaling from the interstitium. How the interstitium orchestrates these various roles is poorly understood. Here, we show that during development the interstitium is a highly heterogeneous patterned population of cells that occupies distinct positions correlated to the adjacent parenchyma. Our analysis indicates that the heterogeneity is not a mere reflection of different stag

SUBMITTER: England AR 

PROVIDER: S-EPMC7438011 | biostudies-literature | 2020 Aug

REPOSITORIES: biostudies-literature