Spontaneous Local Calcium Transients Regulate Oligodendrocyte Development in Culture through Store-Operated Ca²⁺ Entry and Release.

ABSTRACT: Oligodendrocytes (OLs) insulate axonal fibers for fast conduction of nerve impulses by wrapping axons of the CNS with compact myelin membranes. Differentiating OLs undergo drastic chances in cell morphology. Bipolar oligodendroglial precursor cells (OPCs) transform into highly ramified multipolar OLs, which then expand myelin membranes that enwrap axons. While significant progress has been made in understanding the molecular and genetic mechanisms underlying CNS myelination and its disruption in diseases, the cellular mechanisms that regulate OL differentiation are not fully understood. Here, we report that developing rat OLs in culture exhibit spontaneous Ca²⁺ local transients (sCaLTs) in their process arbors in the absence of neurons. Importantly, we find that the frequency of

SUBMITTER: Rui Y 

PROVIDER: S-EPMC7438061 | biostudies-literature | 2020 Jul/Aug

REPOSITORIES: biostudies-literature